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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3C2B All Species: 10.3
Human Site: Y228 Identified Species: 25.19
UniProt: O00750 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00750 NP_002637.3 1634 184768 Y228 R L L G S V D Y D G I N D A I
Chimpanzee Pan troglodytes XP_514126 1613 182398 Y228 R L L G S V D Y D G I N D A I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536097 1864 208404 Y228 R L L G P V D Y D G I N D A I
Cat Felis silvestris
Mouse Mus musculus Q61194 1686 190739 D274 I N K F D W L D L D P L S K P
Rat Rattus norvegicus O70173 1505 170957 L212 V F S K D S F L P R A S E N M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506878 1462 164902 L200 R P P P G K L L G R Q I L E E
Chicken Gallus gallus XP_417956 2032 228776 A222 E E D P Y G L A D Y E G I N D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_696344 1587 179557 S208 K I N G D W L S P G R S R R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524028 1876 210456 V407 V N R W D K T V A T V S P N V
Honey Bee Apis mellifera XP_396869 1681 191083 H235 Q N D N A Q G H K D E M Q S Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 N.A. 81.7 N.A. 44 31.4 N.A. 77.1 64.9 N.A. 63.2 N.A. 33.2 35.3 N.A. N.A.
Protein Similarity: 100 98.5 N.A. 83.9 N.A. 62.6 50.9 N.A. 81.6 70.7 N.A. 76.1 N.A. 49 53.1 N.A. N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 0 0 N.A. 6.6 6.6 N.A. 13.3 N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 0 20 N.A. 6.6 6.6 N.A. 33.3 N.A. 20 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 10 10 0 10 0 0 30 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 20 0 40 0 30 10 40 20 0 0 30 0 10 % D
% Glu: 10 10 0 0 0 0 0 0 0 0 20 0 10 10 10 % E
% Phe: 0 10 0 10 0 0 10 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 40 10 10 10 0 10 40 0 10 0 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 10 10 0 0 0 0 0 0 0 0 30 10 10 0 30 % I
% Lys: 10 0 10 10 0 20 0 0 10 0 0 0 0 10 0 % K
% Leu: 0 30 30 0 0 0 40 20 10 0 0 10 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % M
% Asn: 0 30 10 10 0 0 0 0 0 0 0 30 0 30 0 % N
% Pro: 0 10 10 20 10 0 0 0 20 0 10 0 10 0 10 % P
% Gln: 10 0 0 0 0 10 0 0 0 0 10 0 10 0 10 % Q
% Arg: 40 0 10 0 0 0 0 0 0 20 10 0 10 10 0 % R
% Ser: 0 0 10 0 20 10 0 10 0 0 0 30 10 10 0 % S
% Thr: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % T
% Val: 20 0 0 0 0 30 0 10 0 0 10 0 0 0 10 % V
% Trp: 0 0 0 10 0 20 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 30 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _